28-Deoxonimbolide, a nimbin-type limonoid from Azadirachta indica seed extracts, exhibits anticancer activity. It induces apoptotic cell death in HL60 cells through both mitochondrial and death receptor pathways.
| Formula | C27H32O6 |
|---|---|
| Molecular Weight | 452.54 |
| SMILES | O=C(OC)C[C@@H]([C@]1(C)C2=C(C)[C@H](C3=COC=C3)C[C@@]2([H])O[C@]1([H])[C@@](OC4)([H])[C@@]5([H])[C@@]4(C)C=C6)[C@@]5(C)C6=O |
| Biological Target | Apoptosis; Caspase |
| Target | Caspase-8; Caspase-9; Caspase-3 |
| Initial Source | Plants; Meliaceae; Azadirachta indica A. Juss. |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month |
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