3-Methylglutaric acid

Cat. No. NATM-2505-CXX-24

Package 500 mg/1 g/5 g/10 g

Description

3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, inhibiting rat cortical synaptosomal Na+, K+-ATPase by 30%. It induces ROS generation, causing oxidative damage, and inhibits mitochondrial redox potential and cell membrane ion pump function. It is used to study neuropathological mechanisms of metabolic diseases and oxidative stress-mediated neuronal damage in neurodegeneration.

Product Details

Purity	0.98
Formula	C6H10O4
Molecular Weight	146.14
SMILES	O=C(O)CC(C)CC(O)=O
Appearance	Solid
Color	White to off-white
Biological Target	Na+/K+ ATPase; Mitochondrial Metabolism; Reactive Oxygen Species
Target	Human Endogenous Metabolite
Initial Source	Endogenous metabolite; Disease markers; Endocrine diseases; Endogenous metabolite; Disease markers; Nervous System Disorder; Endogenous metabolite; Disease markers; Cardiovascular System Disorder; Endogenous metabolite; Human Gut Microbiota Metabolites; Microorganisms
Solubility	H2O: 100 mg/mL (684.28 mM); DMSO: 100 mg/mL (684.28 mM, need ultrasonic)
Shipping Conditions	Room Temperature
Storage Information	Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month