4'-Hydroxychalcone

Cat. No. NATM-2505-CXX-26

Package 5 g/10 g/50 g

Description

4'-Hydroxychalcone, a hepatoprotective chalcone from licorice root, inhibits TNFα-induced NF-κB activation via proteasome inhibition. It induces rapid potassium release from mitochondrial vesicles, impairing respiratory control and oxidative phosphorylation in isolated rat liver mitochondria.

Product Details

Purity	99.66%
Formula	C15H12O2
Molecular Weight	224.25
SMILES	O=C(C1=CC=C(O)C=C1)/C=C/C2=CC=CC=C2
Appearance	Solid
Color	Light yellow to yellow
Biological Target	Oxidative Phosphorylation; Proteasome
Initial Source	Plants; Leguminosae; Glycyrrhiza uralensis Fisch.; Endogenous metabolite
Solubility	DMSO: 233.33 mg/mL (1040.49 mM, need ultrasonic)
Shipping Conditions	Room Temperature
Storage Information	Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month