7α-Hydroxy-DHEA

Cat. No. NATM-2505-CXX-30

Package 50 mg/100 mg/250 mg

Description

7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone), a 7α-hydroxylated metabolite of DHEA, is catalyzed by intracellular steroid 7α-hydroxylases like P450 2A1. It exhibits DHEA-comparable biological activity without converting to androgenic or estrogenic compounds. It enhances heat production and reduces food utilization by inducing thermogenic enzymes like mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme. As a more efficient and safer DHEA metabolite, 7α-Hydroxy-DHEA shows potential for studying obesity, metabolic diseases, and adrenal carcinoma.

Product Details

Synonyms	7α-Hydroxydehydroepiandrosterone; 3β, 7α-Dihydroxy-Δ5-androsten-17-one
Formula	C19H28O3
Molecular Weight	304.42
SMILES	C[C@@]12[C@]3([H])[C@]([C@@H](C=C1C[C@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C
Biological Target	Cytochrome P450; Mitochondrial Metabolism
Initial Source	Endogenous metabolite
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month