AG-494

Cat. No. BIAOS-2505-CXX-6

Package 10 mg

Description

Potent, selective inhibitor of EGF receptor tyrosine kinase (IC50 = 0.7 μM); selective over ErbB2, PDGFR tyrosine kinase, and insulin receptor (IC50 = 42, 6, and 100 μM respectively). Inhibits CDK2 activation, causing cell cycle arrest at late G1 and S phase.

Product Details

Formal Name	(E)-2-cyano-3-(3, 4-dihydroxyphenyl)-N-phenylprop-2-enamide
Synonyms	Tyrphostin B48
Purity	>99%
CAS Number	133550-35-3
Formula	C16H12N2O3
Molecular Weight	280.28
Appearance	Solid
Stability	Stable for 12 months
Storage Information	Room Temperature

Application

EGF receptor tyrosine kinase