Arecoline is a covalent inhibitor of mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1), binding and disrupting ACAT1 tetramers (IC50 = 11.1 μM) without affecting ACAT2 and DLAT.
| Formal Name | 1, 2, 5, 6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide |
|---|---|
| Purity | >98% |
| CAS Number | 300-08-3 |
| Formula | C8H13NO2 HBr |
| Molecular Weight | 236.11 |
| Appearance | Powder |
| Solubility | Dissolves in water (up to 50 mg/mL). |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in Water (up to 50 mg/mL), and then dilute it into an aqueous buffer. Solutions are not stable – make fresh daily. |
| Storage Information | Room Temperature |
ACAT1 inhibitor
Datasheet