It depolarizes mitochondrial membranes by generating ROS, disrupting the electron transport chain; ROS generation depends on RIP1. Inhibits TNFα-induced proinflammatory cytokine production in human RA synoviocytes.
| Formal Name | Succinyl dihydroartemisinin |
|---|---|
| Purity | >98% |
| CAS Number | 88495-63-0 |
| Formula | C19H28O8 |
| Molecular Weight | 384.42 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 25 mg/mL) or in ethanol (up to 20 mg/mL). |
| Stability | ≥ 1 year |
| Application Procedures | First, dissolve in DMSO (up to 25 mg/mL) or in Ethanol (up to 20 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO or ethanol can be stored at -20°C for up to 1 month. |
| Storage Information | -20°C |
Cancer stem cell inhibitor
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