A cell-permeable small molecule mimicking the BH3 domain of Bcl-2 inhibitors, interfering with Bcl-2-family antiapoptotic proteins. It induces apoptosis via the mitochondrial pathway in drug-resistant multiple myeloma cells.
| Synonyms | Gossypol R(-) |
|---|---|
| Purity | >98% |
| CAS Number | 90141-22-3 |
| Formula | C30H30O8 |
| Molecular Weight | 518.56 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 50 mg/mL) or in ethanol (up to 50 mg/mL). |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in DMSO (up to 50 mg/mL) or in Ethanol (up to 50 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO or ethanol can be stored at -20°C for up to 1 month. |
| Storage Information | -20°C |
Bcl-2 inhibitor
Datasheet