Auranofin is a DMARD that potently inhibits selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. It efficiently induces mitochondrial membrane permeability transition pore opening in the presence of calcium ions.
| Formal Name | 1-Thio-ß-D-glucopyranosatotriethylphosphine gold-2, 3, 4, 6-tetraacetate |
|---|---|
| Synonyms | SKF-39162 |
| Purity | >98% |
| CAS Number | 34031-32-8 |
| Formula | C20H34AuO9PS |
| Molecular Weight | 678.49 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 5 mg/mL) or in ethanol (up to 4 mg/mL). |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in DMSO (up to 5 mg/mL) or in Ethanol (up to 4 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO or ethanol can be stored at -20° for up to 2 months. |
| Storage Information | Room Temperature |
IKK inhibitor
Datasheet