Azadirachtin is an orally active triterpenoid with anticancer, antimalarial, anti-inflammatory, and insecticidal properties. It induces cell apoptosis via the mitochondrial pathway (inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3) or death receptors (inhibiting TNFR activation).
| Purity | 99.06% |
|---|---|
| Formula | C35H44O16 |
| Molecular Weight | 720.71 |
| SMILES | C[C@@]1([C@@]([C@@]2(O)C(OC)=O)([H])[C@]([C@H](C[C@H]3OC(C)=O)OC(/C(C)=C/C)=O)(CO2)[C@@]4([H])[C@](OC[C@@]43C(OC)=O)([H])[C@H]1O)[C@]([C@@H](O[C@]5([H])OC=C6)C[C@H]7[C@]56O)(O8)[C@]78C |
| Appearance | Solid |
| Color | White to light yellow |
| Biological Target | Apoptosis; Parasite; NF-κB; Bcl-2 Family; Caspase |
| Target | Caspase 3 |
| Initial Source | Plants; Meliaceae; Azadirachta indica A. Juss. |
| Solubility | DMSO: 100 mg/mL (138.75 mM) |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month |
Datasheet