Bruceantin ((-)-Bruceantin), a quassinoid from B. javanica, activates the caspase pathway, causes mitochondrial dysfunction, inhibits cell proliferation, and induces cell differentiation and apoptosis. It exhibits anti-leukemia and antiprotozoal activities.
| Synonyms | (-)-Bruceantin; NCI165563; NSC165563 |
|---|---|
| Purity | 99.67% |
| Formula | C28H36O11 |
| Molecular Weight | 548.58 |
| SMILES | O=C([C@@]1([C@H]([C@H](O)[C@]2([H])[C@]3(C4)C)O)[C@@]([C@H](C5=O)OC(/C=C(C)/C(C)C)=O)([H])[C@@]2([C@@](O5)([H])C[C@@]3([H])C(C)=C(O)C4=O)CO1)OC |
| Appearance | Solid |
| Color | White to off-white |
| Biological Target | c-Myc; Caspase; Mitochondrial Metabolism; Apoptosis; Parasite |
| Initial Source | Plants; Simaroubaceae; Brucea javanica (L.) Merr.; Plants; Simaroubaceae; Brucea antidysenterica J.F.Mill. |
| Solubility | DMSO: 100 mg/mL (182.29 mM, need ultrasonic) |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month |
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