Calenduloside E

Cat. No. NATM-2505-CXX-52

Package 5 mg/10 mg/25 mg/50 mg/100 mg/200 mg

Description

Calenduloside E, a pentacyclic triterpenoid saponin from Aralia ovata bark and roots, has anti-inflammatory and anti-apoptotic properties. It alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function via the AMPK-SIRT3 pathway, and mitigates acute liver injury. Additionally, it promotes L-type calcium channel interaction with Bcl-2 related apoptosis genes, inhibiting calcium overload and alleviating myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways and inhibits ROS-mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses.

Product Details

Purity	99.07%
Formula	C36H56O9
Molecular Weight	632.82
SMILES	C[C@]12[C@]3(C([C@@]4([H])[C@](C(O)=O)(CCC(C)(C)C4)CC3)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](O[C@]6([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)CC5)C)([H])CC2)C)C
Appearance	Solid
Color	White to off-white
Biological Target	Apoptosis; Pyroptosis; AMPK; Bcl-2 Family; JAK; STAT; Calcium Channel; Interleukin Related; TNF Receptor; SOD; Reactive Oxygen Species; PPAR
Initial Source	Plants; Araliaceae; Aralia elata (Miq.) Seem.; Plants; other families; Endogenous metabolite
Solubility	DMSO: 100 mg/mL (158.02 mM, need ultrasonic)
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month