A potent and selective SGLT2 inhibitor (IC50 = 2.2 nM) that increases glucose excretion dose-dependently in healthy subjects. It inhibits cancer cell proliferation by blocking mitochondrial complex I-supported respiration.
| Formal Name | (1S)-1, 5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol |
|---|---|
| Synonyms | JNJ-24831754 |
| Purity | >98% |
| CAS Number | 842133-18-0 |
| Formula | C24H25FO5S |
| Molecular Weight | 444.5 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 40 mg/mL) |
| Stability | ≥ 1 year |
| Application Procedures | First, dissolve in DMSO (up to 40 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 1 month. |
| Storage Information | -20°C |
SGLT2 inhibitor
Datasheet