Inhibits the mitochondrial Na⁺-Ca²⁺ exchanger (NCX) in heart mitochondria (IC₅₀=0.36 μM) without affecting plasmalemmal NCX. Also inhibits voltage-gated Ca²⁺ channels in intact cells, requiring controls in studies.
| Formal Name | 7-Chloro-5-(2-chlorophenyl)-1, 5-dihydro-4, 1-benzothiazepin-2(3H)-one |
|---|---|
| Purity | >98% |
| CAS Number | 75450-34-9 |
| Formula | C15H11Cl2NOS |
| Molecular Weight | 324.22 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 25 mg/mL). |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in DMSO (up to 25 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 3 months. |
| Storage Information | Room Temperature |
Mitochondrial Na+/Ca2+ exchanger inhibitor
Datasheet