Chaetoglobosin E

Cat. No. NATM-2505-CXX-57

Package 50 mg/100 mg/250 mg

Description

Chaetoglobosin E is a ferroptosis inducer with significant cytotoxicity against human tumor cell lines MDA-MB231 (IC50=9.14 μM) and A549 (IC50=7.47 μM). It downregulates GPX4 in A549 cells, increasing intracellular Fe2+ and MDA, leading to mitochondrial shrinkage, cristae reduction, and ferroptosis induction. It's used in cancer research.

Product Details

Formula	C32H38N2O5
Molecular Weight	530.65
SMILES	CC1=C(C)[C@]([C@@H](N2)CC3=CNC4=C3C=CC=C4)([H])[C@@]([C@](/C=C/C[C@H](C)/C=C5\C)([H])[C@@H]1O)(C(CC[C@H](O)C5=O)=O)C2=O
Biological Target	Ferroptosis
Initial Source	Microorganisms; endophytic Chaetomium sp
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month