Citronellol

Cat. No. NATM-2505-CXX-59

Package 500 mg/1 g/5 g

Description

Citronellol ((±)-Citronellol) is an orally active apoptosis inducer. It prevents oxidative stress, mitochondrial dysfunction, and apoptosis in 6-OHDA-induced SH-SY5Y Parkinson's disease models by regulating ROS-NO, MAPK/ERK, and PI3K/Akt pathways. It induces necroptosis in human lung cancer cells via the TNF-α pathway and ROS accumulation. Citronellol reduces LC-3 and p62 levels to regulate autophagy, inhibits oxidative stress and neuroinflammation, providing neuroprotection in Parkinson's rats. It also exhibits antifungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.

Product Details

Synonyms	(±)-Citronellol; (±)-β-Citronellol
Purity	98.60%
Formula	C10H20O
Molecular Weight	156.27
SMILES	CC(CCC=C(C)C)CCO
Appearance	Liquid
Color	Less to light yellow
Biological Target	Reactive Oxygen Species; ERK; PI3K; TNF Receptor; Atg8/LC3; p62; Apoptosis; Necroptosis; Autophagy; Fungal
Target	IC50: 54.02, 40.64, 52.51, 45.84, 50.1 μg/mL (A549、NCI-H1299、NCI-H23、BT-20、PC3 cells) (Apoptosis)
Initial Source	Plants; Geraniaceae; Microorganisms
Solubility	DMSO: 100 mg/mL (639.92 mM)
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month