It binds strongly to hydroxyapatite, reducing osteoclast activity. Metabolized to a cytotoxic ATP analog (AppCCl2p) that inhibits mitochondrial ADP/ATP translocase, leading to osteoclast apoptosis.
| Formal Name | Dichloromethylenediphosphonic acid disodium tetrahydrate |
|---|---|
| Purity | >98% |
| CAS Number | 88416-50-6 |
| Formula | CH2Cl2O6P2·2Na·4H2O |
| Molecular Weight | 360.92 |
| Appearance | Powder |
| Solubility | Dissolves in water (up to at least 10 mg/mL) |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in water (up to at least 10 mg/mL), and then dilute it into an aqueous buffer. Solutions in distilled water can be stored at -20°C for up to 3 months. |
| Storage Information | -20°C |
Bis-phosphonate; Osteoclast apoptosis agent
Datasheet