Dehydrobruceine B, a quassinoid from Brucea javanica, synergistically induces apoptosis with Cisplatin via a mitochondrial pathway. It increases AIF and Bax expression and suppresses Keap1-Nrf2.
| Formula | C23H26O11 |
|---|---|
| Molecular Weight | 478.45 |
| SMILES | COC([C@]12[C@@]3([H])[C@@]4(CO2)[C@@]([C@H]([C@@H]1O)O)([H])[C@@]5(C(C[C@@]4([H])OC([C@@H]3OC(C)=O)=O)=C(C(C(O)=C5)=O)C)C)=O |
| Biological Target | Bcl-2 Family; Keap1-Nrf2; Apoptosis |
| Target | Bax; Bcl-xL; Bcl-2 |
| Initial Source | Microorganisms; B. antidysenterica and B. guineensis |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month |
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