Desmosterol

Cat. No. NATM-2505-CXX-69

Package 5 mg/10 mg/25 mg/50 mg/100 mg/200 mg/500 mg

Description

Desmosterol, a cholesterol-like molecule and direct precursor in the Bloch pathway of cholesterol biosynthesis, is used as an endogenous metabolite to study cholesterol metabolism. It activates LXR and inhibits SREBP, suppressing macrophage inflammasome activation and preventing vascular inflammation and atherosclerosis. Reduced Desmosterol promotes mitochondrial ROS production in macrophages and NLRP3 inflammasome activation. It shows potential for research in inflammation, metabolism, and cardiovascular diseases.

Product Details

Purity	0.98
Formula	C27H44O
Molecular Weight	384.64
SMILES	C/C(C)=C\CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Appearance	Solid
Color	White to off-white
Biological Target	Endogenous Metabolite; LXR; Fatty Acid Synthase (FASN); Interleukin Related; Reactive Oxygen Species; NOD-like Receptor (NLR)
Target	Human Endogenous Metabolite
Initial Source	Endogenous metabolite; Disease markers; Endocrine diseases; Microorganisms
Solubility	DMF: 50 mg/mL (129.99 mM, need ultrasonic); H2O: < 0.1 mg/mL (insoluble)
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month