Destruxin B

Cat. No. NATM-2505-CXX-71

Package 1 mg/5 mg/10 mg

Description

Destruxin B, a cyclodepsipeptide isolated from entomopathogenic fungus Metarhizium anisopliae, exhibits insecticidal and anticancer activities. It induces apoptosis in human non-small cell lung cancer cells via a Bcl-2 Family-dependent mitochondrial pathway. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis in vitro and in vivo.

Product Details

Purity	99.35%
Formula	C32H55N5O7
Molecular Weight	621.81
SMILES	O=C(N[C@]([C@@H](C)CC)(C)C(N(C)[C@@H](C(C)C)C(N(C)[C@@H](C)C(NCC1)=O)=O)=O)[C@@](CCC2)(C)N2C([C@@H](CC(C)C)OC1=O)=O
Appearance	Solid
Color	White to off-white
Biological Target	Bcl-2 Family; Caspase; Apoptosis
Target	Bcl-2; Caspase-3
Initial Source	Microorganisms; Metarhizium anisopliae
Solubility	Ethanol: 12.5 mg/mL (20.10 mM, need ultrasonic and warming)
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month