DL-Mevalonolactone ((±)-Mevalonolactone; Mevalolactone), the δ-lactone of mevalonic acid, is a mevalonate pathway precursor. This orally active compound combats HMGCR mutation and statin-induced myopathy. It also induces inflammation and oxidative stress, decreasing MMP and causing mitochondrial swelling.
| Synonyms | (±)-Mevalonolactone; Mevalolactone |
|---|---|
| Purity | 99.15% |
| Formula | C6H10O3 |
| Molecular Weight | 130.14 |
| SMILES | O=C1CC(C)(O)CCO1 |
| Appearance | <28°C Solid, >28°C Liquid |
| Color | Less to light yellow |
| Biological Target | Endogenous Metabolite |
| Target | Human Endogenous Metabolite |
| Initial Source | Endogenous metabolite |
| Solubility | DMSO: 100 mg/mL (768.40 mM, need ultrasonic); H2O: 50 mg/mL (384.20 mM, need ultrasonic) |
| Shipping Conditions | Room Temperature |
| Storage Information | Pure form: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month |
Datasheet