GO-203 TFA

Cat. No. MRP-2505-CXX-16

Package 1 mg/5 mg/10 mg/50 mg/100 mg

Description

GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. This all-D-amino acid peptide, with a poly-R transduction domain linked to a CQCRRKN motif, binds the MUC1-C cytoplasmic tail to block homodimerization. It downregulates TIGAR synthesis by inhibiting the PI3K-AKT-S6K1 pathway, induces ROS production and mitochondrial transmembrane potential loss, and inhibits colon cancer cell growth in vitro and in vivo.

Product Details

Purity	99.28%
Formula	C89H171F3N52O21S2
Molecular Weight	2426.77
Appearance	Solid
Color	White to off-white
Biological Target	PI3K; Reactive Oxygen Species; Apoptosis
Research Areas	Cancer
Sequence	d-{Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Cys-Gln-Cys-Arg-Arg-Lys-Asn} (TFA salt)
Sequence Shortening	d-{Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Cys-Gln-Cys-Arg-Arg-Lys-Asn} (TFA salt)
Solubility	DMSO: 100 mg/mL (41.21 mM, need ultrasonic); H2O: 100 mg/mL (41.21 mM, need ultrasonic)
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C (2 years), -20°C (1 year); In solvent: -80°C (6 months), -20°C (1 month)