Hederagenin

Cat. No. NATM-2505-CXX-100

Package 5 mg/10 mg/25 mg/50 mg/100 mg/200 mg

Description

Hederagenin is an orally active triterpenoid saponin with antitumor activity. It inhibits LPS-induced iNOS, COX-2, and NF-κB expression in cells. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. It sensitizes cancer cells to Cisplatin and Paclitaxel, enhancing apoptosis, and shows preventive potential against alcoholic liver injury.

Product Details

Purity	99.95%
Formula	C30H48O4
Molecular Weight	472.70
SMILES	CC1(C)CC[C@@](CC[C@]2(C)C3=CC[C@@]4([H])[C@@]2(C)CC[C@]5([H])[C@]4(C)CC[C@H](O)[C@]5(CO)C)(C(O)=O)[C@@]3([H])C1
Appearance	Solid
Color	White to off-white
Biological Target	COX; NF-κB
Initial Source	Plants; Araliaceae; Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd.
Solubility	DMSO: 50 mg/mL (105.78 mM, need ultrasonic)
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month