A synthetic bis-dichloroacetate ester of honokiol that allosterically inhibits mitochondrial chaperone TRAP1 (IC50 ~ 8 µM). TRAP1 inhibition upregulates succinate dehydrogenase and mitochondrial deacetylase SIRT3.
| Formal Name | Honokiol bis-dichloroacetate |
|---|---|
| Synonyms | HDCA |
| Purity | >98% |
| CAS Number | 1620160-42-0 |
| Formula | C22H18Cl4O4 |
| Molecular Weight | 488.2 |
| Appearance | Oil |
| Solubility | Dissolves in DMSO (up to 50 mg/mL) |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in DMSO (up to 50 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 1 month. |
| Storage Information | -20°C |
TRAP1 inhibitor
Datasheet