IACS-010759 is a potent (IC50 = 1.1 nM) and selective inhibitor of mitochondrial complex I. It shows in vivo efficacy in glycolysis-deficient glioblastoma and AML models without harming normal cells, due to its unique binding site on complex I.
| Formal Name | 5-[5-Methyl-1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-1, 2, 4-triazol-3-yl]-3-[4-(trifluoromethoxyphenyl]-1, 2, 4-oxadiazole |
|---|---|
| Purity | >98% |
| CAS Number | 1570496-34-2 |
| Formula | C25H25F3N6O4S |
| Molecular Weight | 562.6 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (25 mg/mL) |
| Stability | ≥ 1 year |
| Application Procedures | First, dissolve in DMSO (25 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 3 months. |
| Storage Information | -20°C |
Mitochondrial Complex I Inhibitor
Datasheet