IM156 is a potent AMPK activator with greater activity than metformin or AICAR. IM156 induces metabolic stress in Myc+ lymphoma cells by inhibiting TCA cycle metabolism and mitochondrial respiration (inhibiting complex I).
| Formal Name | N’-[N’-[4-(Trifluoromethoxy)phenyl]carbamimidoyl]pyrrolidine-1-carboxamidine |
|---|---|
| Synonyms | HL156A |
| Purity | >98% |
| CAS Number | 1422365-93-2 |
| Formula | C13H16F3N5O |
| Molecular Weight | 315.3 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 25 mg/mL) |
| Stability | ≥ 1 year |
| Application Procedures | First, dissolve in DMSO (up to 25 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 2 months. |
| Storage Information | -20°C |
AMPK activator/Mitochondrial protein complex I inhibitor
Datasheet