L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. It inhibits histone demethylases, promoting histone methylation. It also inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki values of 2.52 mM and 11.13 mM, respectively.
| Synonyms | (S)-2-Hydroxyglutaric acid disodium |
|---|---|
| Purity | 99.12% |
| Formula | C5H6Na2O5 |
| Molecular Weight | 192.08 |
| SMILES | O=C(O[Na])[C@@H](O)CCC(O[Na])=O |
| Appearance | Solid |
| Color | White to off-white |
| Biological Target | Histone Demethylase; Mitochondrial Metabolism; Endogenous Metabolite |
| Target | Human Endogenous Metabolite |
| Initial Source | Endogenous metabolite |
| Solubility | H2O: 83.33 mg/mL (433.83 mM, need ultrasonic) |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month |
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