Inhibits serine palmitoyltransferase, down-regulating sphingolipid biosynthesis. Inhibition of ceramide biosynthesis with L-cycloserine improves the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in cortical neurons.
| Formal Name | (S)-4-Amino-3-isoxazolidinone |
|---|---|
| Synonyms | L-(-)-Cycloserine; S-Cycloserine |
| Purity | >98% |
| CAS Number | 339-72-0 |
| Formula | C3H6N2O2 |
| Molecular Weight | 102.1 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 20 mg/mL, warm) or in water (up to 25 mg/mL). |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in DMSO (20 mg/mL) or in Water (25 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO or water can be stored at -20°C for up to 1 month. |
| Storage Information | -20°C |
Sphingolipid biosynthesis inhibitor
Datasheet