α-Lipoic Acid (Thioctic acid) is an antioxidant and a key cofactor for mitochondrial enzyme complexes. It inhibits NF-κB-dependent HIV-1 LTR activation and induces ER stress-mediated apoptosis in hepatoma cells. It can also be used with CPUL1 to create the CPUL1-LA NA nanoaggregate, enhancing antitumor efficacy.
| Synonyms | Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid |
|---|---|
| Purity | 99.86% |
| Formula | C8H14O2S2 |
| Molecular Weight | 206.33 |
| SMILES | O=C(O)CCCCC1SSCC1 |
| Appearance | Solid |
| Color | Light yellow to yellow |
| Biological Target | NF-κB; HIV; Mitochondrial Metabolism; Endogenous Metabolite; Apoptosis |
| Target | Human Endogenous Metabolite; NF-κB; Mitochondrial bioenergetics; HIV-1 |
| Initial Source | Endogenous metabolite |
| Solubility | DMSO: 100 mg/mL (484.66 mM, need ultrasonic); H2O: < 0.1 mg/mL (insoluble) |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 2 years; -20°C, 1 year |
Datasheet