Lonidamine

Cat. No. BIAMM-2505-CXX-11

Package 10 mg/50 mg

Description

This indazole-3-carboxylic acid derivative inhibits mitochondria-bound hexokinase, reducing aerobic and anaerobic glycolysis in Ehrlich ascites tumor cells (IC50 = 90 µM and 45 µM). It causes intracellular acidification by inhibiting lactate transport and also inhibits the mitochondrial pyruvate carrier (Ki = 2.5 µM), monocarboxylate transporter isozymes, and succinate-ubiquinone reductase activity of complex II.

Product Details

Formal Name	1-[(2, 4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Synonyms	AF1890; Diclondazolic acid
Purity	>98%
CAS Number	50264-69-2
Formula	C15H10Cl2N2O2
Molecular Weight	321.2
Appearance	Powder
Solubility	Dissolves in DMSO (up to 25 mg/mL).
Stability	≥ 1 year
Application Procedures	First, dissolve in DMSO (up to 25 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 1 month.
Storage Information	-20°C

Application

Inhibits cancer cell metabolism