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Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). It induces mitochondrial dysfunction, ROS production, DNA fragmentation, and increases acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy, and necrosis, making it useful for Chagas disease research.
| Formula | C25H26O5 |
|---|---|
| Molecular Weight | 406.47 |
| SMILES | O=C1C=C(C2=CC=CC=C2)C3=C(O)C(C/C=C(C)\C)=C(O)C(C(CC(C)C)=O)=C3O1 |
| Biological Target | Parasite; Apoptosis; Autophagy; Reactive Oxygen Species |
| Target | T. cruzi |
| Initial Source | Plants; other families; Calophyllum brasiliense auct. non Camb. |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month |