Metolazone is a useful diuretic that inhibits the thiazide-sensitive Na±Cl– cotransporter (NCC) (IC50 = 0.3 µM in rats), blocking sodium reabsorption. Additionally, it activates the mitochondrial unfolded protein response (UPRMT) and extends C. elegans lifespan.
| Formal Name | 7-Chloro-1, 2, 3, 4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide |
|---|---|
| Synonyms | SR 720-22 |
| Purity | >98% |
| CAS Number | 17560-51-9 |
| Formula | C16H16ClN3O3S |
| Molecular Weight | 365.8 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (36 mg/mL) |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in DMSO (36 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 2 months. |
| Storage Information | -20°C |
UPR activator and longevity inducer
Datasheet