Nigericin sodium salt, an antibiotic from Streptomyces hygroscopicus, acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. It's an NLRP3 activator with promising anticancer activities, achieved by decreasing intracellular pH (pHi) and inactivating Wnt/β-catenin signals. It also induces pyroptosis through caspase 1/GSDMD in TNBC.
| Purity | 99.37% |
|---|---|
| Formula | C40H67NaO11 |
| Molecular Weight | 746.94 |
| SMILES | C[C@H]1[C@](O[C@@H]2C[C@](CC[C@@H]3C)([H])O[C@@]3([H])[C@@H](C)C(O[Na])=O)([C@@H]([C@H](OC)C2)C)O[C@](C)([C@@]4([H])O[C@@](C)([C@@]5([H])O[C@@]([C@]([C@@H](C[C@@H]6C)C)([H])O[C@]6(O)CO)([H])C[C@H]5C)CC4)C1 |
| Appearance | Solid |
| Color | White to off-white |
| Biological Target | Potassium Channel; NOD-like Receptor (NLR); Bacterial; Antibiotic; Pyroptosis; Wnt; β-catenin |
| Target | NLRP3 |
| Initial Source | Microorganisms; Streptomyces hygroscopicus |
| Solubility | Ethanol: 25 mg/mL (33.47 mM, need ultrasonic) |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month |
Datasheet