Orotic acid (6-Carboxyuracil), a pyrimidine nucleotide and RNA precursor, is released from mitochondrial DHODH for cytoplasmic UMP synthase conversion to UMP. It's a marker for newborn screening of urea cycle disorders and can induce hepatic steatosis and hepatomegaly in rats.
| Synonyms | 6-Carboxyuracil; Vitamin B13 |
|---|---|
| Purity | 99.98% |
| Formula | C5H4N2O4 |
| Molecular Weight | 156.10 |
| SMILES | O=C(C(NC1=O)=CC(N1)=O)O |
| Appearance | Solid |
| Color | White to off-white |
| Biological Target | Nucleoside Antimetabolite/Analog; Endogenous Metabolite |
| Target | Human Endogenous Metabolite |
| Initial Source | Endogenous metabolite; Disease markers; Endocrine diseases; Endogenous metabolite; Disease markers; Nervous System Disorder; Endogenous metabolite; Human Gut Microbiota Metabolites; Microorganisms |
| Solubility | DMSO: 50 mg/mL (320.31 mM, ultrasonic and warming and heat to 60°C); H2O: < 0.1 mg/mL (insoluble) |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month |
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