Orotic acid (zinc), a precursor in pyrimidine nucleotide and RNA biosynthesis, is released from mitochondrial DHODH for cytoplasmic UMP synthase conversion to UMP. It's a marker for newborn screening of urea cycle disorders and can induce hepatic steatosis and hepatomegaly in rats.
| Synonyms | 6-Carboxyuracil zinc; Vitamin B13 zinc |
|---|---|
| Purity | 99.84% |
| Formula | C5H4N2O4Zn0.5 |
| Molecular Weight | 188.79 |
| SMILES | O=C(C(NC1=O)=CC(N1)=O)O.[0.5Zn] |
| Appearance | Solid |
| Color | White to off-white |
| Biological Target | Nucleoside Antimetabolite/Analog; Endogenous Metabolite |
| Target | Human Endogenous Metabolite |
| Initial Source | Endogenous metabolite |
| Solubility | DMSO: 20 mg/mL (105.94 mM, ultrasonic and adjust pH to 2 with 1 M HCL) |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month |
Datasheet