Paris saponin VII

Cat. No. NATM-2505-CXX-163

Package 5 mg/10 mg/50 mg/100 mg

Description

Paris saponin VII (Chonglou Saponin VII), a steroidal saponin from Trillium tschonoskii, induces apoptosis in K562/ADR cells via Akt/MAPK and P-gp inhibition. It attenuates mitochondrial membrane potential, increases apoptosis-related proteins (e.g., Bax, cytochrome c), and decreases Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt levels. It also induces robust autophagy in K562/ADR cells, providing a biochemical basis for leukemia treatment.

Product Details

Synonyms	Chonglou Saponin VII
Purity	99.96%
Formula	C51H82O21
Molecular Weight	1031.18
SMILES	O[C@@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@@]5(C(C[C@@H](O[C@@]6([H])[C@@H]([C@H]([C@H](O[C@@]7([H])[C@@H]([C@@H]([C@@H](O[C@@]8([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O8)O)O)[C@H](C)O7)O)O)[C@@H](CO)O6)O)O[C@@]9([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O9)O)O)CC5)=CC4)C)([H])CC3)([H])C[C@]1([H])O[C@]%10(CC[C@@H](C)CO%10)[C@H]2C)C
Appearance	Solid
Color	White to off-white
Biological Target	Akt; p38 MAPK; P-glycoprotein; Bcl-2 Family; Caspase; PARP; Autophagy; Apoptosis
Target	p38; Bcl-2; Caspase-9; Caspase-3; PARP-1
Initial Source	Plants; Liliaceae; Trillium tschonoskii Maxim.
Solubility	DMSO: 100 mg/mL (96.98 mM, need ultrasonic); H2O: < 0.1 mg/mL (insoluble)
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month