Petasin

Cat. No. NATM-2505-CXX-166

Package 50 mg/100 mg/250 mg

Description

Petasin inhibits adipogenesis in 3T3-F442A cells (IC50 of 0.95 μM). It inhibits lipid synthesis factors ACC1, FAS, and SCD1 by targeting transcription factors PPARγ and C/EBPα, along with TRPA1 and TRPV1 channels. Petasin inhibits mitochondrial complex I, thus suppressing tumor growth and metastasis. It also activates the AMPK pathway, regulating glucose and lipid metabolism. Petasin is orally active.

Product Details

Formula	C20H28O3
Molecular Weight	316.43
SMILES	C[C@@]12C(CC[C@H]([C@@H]2C)OC(/C(C)=C\C)=O)=CC([C@@H](C1)C(C)=C)=O
Biological Target	AMPK; PPAR; TRP Channel; Mitochondrial Metabolism
Initial Source	Plants; Leguminosae; Piptadenia Benth.; Plants; Compositae
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month