PF-543 is a potent (IC50 = 2.0 nM), over 100-fold selective reversible inhibitor of sphingosine kinase-1 (SphK1) over SphK2. It mitigates pulmonary fibrosis by reducing mitochondrial DNA damage and monocyte recruitment.
| Formal Name | [(2R)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol hydrochloride |
|---|---|
| Purity | >98% |
| CAS Number | 1706522-79-3 |
| Formula | C27H31NO4S·HCl |
| Molecular Weight | 502.1 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (50 mg/mL); or water (5 mg/mL with warming) |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in DMSO (50 mg/mL); or Water (5 mg/mL with warming), and then dilute it into an aqueous buffer. Solutions in DMSO or water can be stored at -20°C for up to 3 months. |
| Storage Information | -20°C |
Sphingosine kinase-1 inhibitor
Datasheet