Phosphocreatine (creatine phosphate), an organic compound in vertebrate skeletal muscles, enhances antioxidant activity and activates the TAK1 pathway to protect the heart. It normalizes mitochondrial function and reduces oxidative stress via the Akt-mediated Nrf2/HO-1 pathway. Phosphocreatine also provides renal protection by suppressing apoptosis and ROS generation through the ERK-mediated Nrf-2/HO-1 pathway.
- Home
- Mitochondrial Diseases & Models
- By System Involvement
- Systemic Mitochondrial Disease
- Alpers Disease
- Barth Syndrome
- Carnitine Deficiency
- Creatine Deficiency Syndromes
- Co-Enzyme Q10 Deficience
- Friedreich’s Ataxia
- Kearns-Sayre Syndrome
- Lactic Acidosis
- Leigh Syndrome
- Mitochondrial DNA Depletion Syndrome
- MELAS Syndrome
- Multiple Mitochondrial Dysfunction Syndrome
- Short-Chain Acyl-CoA Dehydrogenase Deficiency
- Thymidine Kinase 2 Deficiency
- Mitochondrial Neurogastrointestinal Encephalopathy
- Organ-specific Mitochondrial Diseases
- Systemic Mitochondrial Disease
- By Etiology
- By System Involvement
- Solutions
- Products
- Mitochondrial Isolation Reagents & Kits
- Mitochondrial Staining Reagents & Kits
- Mitochondrial Disease Diagnostic Reagents & Kits
- Biochemical Inhibitors & Activators
- Mitochondrial Specific Antibodies
- Mitochondrial Recombinant Proteins
- Mitochondria Related Peptides
- Natural Products Targeting Mitochondria
- Resource
- Company