PK-11195 is a selective and potent antagonist of the peripheral benzodiazepine receptor (PBR or TSPO). It chemosensitizes tumor cells to various chemotherapeutic agents via PBR-independent pathways and induces apoptosis in multiple cell lines.
| Formal Name | 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide |
|---|---|
| Purity | >98% |
| CAS Number | 85532-75-8 |
| Formula | C21H21ClN2O |
| Molecular Weight | 352.86 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 25 mg/mL) or in ethanol (up to 15 mg/mL). |
| Stability | ≥ 1 year |
| Application Procedures | First, dissolve in DMSO (up to 25 mg/mL) or in Ethanol (up to 15 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored under nitrogen or argon at -20° for up to 1 month. |
| Storage Information | Room Temperature |
Mitochondrial BZD receptor ligand
Datasheet