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PKHB1, a thrombospondin-1 peptide mimic, exhibits antitumor effects. It induces mitochondrial alterations, ROS production, intracellular Ca2+ accumulation, and calcium-dependent cell death in breast cancer cells. PKHB1 also activates the immune system via immunogenic cell death induction.
| Formula | C68H105N17O12S |
|---|---|
| Molecular Weight | 1384.73 |
| Biological Target | Reactive Oxygen Species; Thrombopoietin Receptor |
| Research Areas | Inflammation/Immunology, Cancer |
| Sequence | {d-Lys}-Arg-Phe-Tyr-Val-Val-Met-Trp-Lys-{d-Lys} |
| Sequence Shortening | {d-Lys}-RFYVVMWK-{d-Lys} |
| Shipping Conditions | Room Temperature |
| Storage Information | Powder: -80°C (2 years), -20°C (1 year); In solvent: -80°C (6 months), -20°C (1 month) |