Q14

Cat. No. MRP-2505-CXX-32

Package 50 mg/100 mg/250 mg

Description

Q14, a polypeptide derived from the transmembrane domain, inhibits USP30 deubiquitination activity (IC50=57.2 nM). It reduces USP30 activity by blocking the interaction between its transmembrane and catalytic domains. Containing an LC3 interaction region (LIR) motif, Q14 binds to LC3 and accelerates autophagosome formation, promoting mitophagy. It's useful for studying neurodegenerative diseases, mitochondrial quality control, and cell metabolism.

Product Details

Synonyms	Q14 peptide
Formula	C101H168N32O23
Molecular Weight	2198.62
Biological Target	Deubiquitinase; Mitophagy
Research Areas	Neurological Disease, Others
Sequence	Ac-Gly-Ile-Tyr-Val-Ile-Trp-Gly-Pro-Ile-Thr-Glu-Arg-Lys-Lys-Arg-Arg-Lys-Gly-NH2
Sequence Shortening	Ac-GIYVIWGPITERKKRRKG-NH2
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C (2 years), -20°C (1 year); In solvent: -80°C (6 months), -20°C (1 month)