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RECTAS is a pre-mRNA splice modulator discovered to correct aberrant IKBKAP splicing in familial dysautonomia cells. Combined with phenylbutyric acid, RECTAS restores DJ-1 protein levels and mitochondrial function in Parkinson’s disease models.
| Formal Name | 2-Chloro-N-(2-furanylmethyl)-9H-purin-6-amine |
|---|---|
| Purity | >98% |
| CAS Number | 101862-47-9 |
| Formula | C10H8ClN5O |
| Molecular Weight | 249.7 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (27 mg/mL) |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in DMSO (27 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 3 months. |
| Storage Information | -20°C |
pre-mRNA splicing modulator