RK-33 is an inhibitor of RNA helicase DDX3 (IC50 = 4.4–8.4 µM) in high DDX3-expressing lung cancer cell lines (A549, H1299, H23, H460). RK-33 causes radiosensitization in breast cancer by inhibiting mitochondrial translation.
| Formal Name | 3, 7-Bis(4-methoxybenzyl)-3, 7-dihydro-1, 3, 4, 6, 7, 9-hexaza-2H-cyclopenta[e]azulene-2-one |
|---|---|
| Purity | >98% |
| CAS Number | 1070773-09-9 |
| Formula | C23H20N6O3 |
| Molecular Weight | 428.44 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 20 mg/mL) |
| Stability | ≥ 1 year |
| Application Procedures | First, dissolve in DMSO (up to 20 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20° for up to 1 month. |
| Storage Information | -20°C |
DDX3 inhibitor
Datasheet