Rotenone, the most common rotenoid, inhibits mitochondrial complex I (IC50 = 1.7–2.2 μM) and NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM).
| Formal Name | (2R, 6aS, 12aS)-1, 2, 12, 12a-Tetrahydro-8, 9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3, 4-b]furo[2, 3-h][1]benzopyran-6(6aH)-one |
|---|---|
| Synonyms | Nicouline; NSC-26285 |
| Purity | >98% |
| CAS Number | 83-79-4 |
| Formula | C23H22O6 |
| Molecular Weight | 394.4 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to 50 mg/mL) |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in DMSO (50 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 3 months. |
| Storage Information | Room Temperature |
Mitochondrial Complex I Inhibitor
Datasheet