Rottlerin

Cat. No. NATM-2505-CXX-176

Package 5 mg/10 mg/25 mg/50 mg/100 mg

Description

Rottlerin, a natural product from Mallotus Philippinensis, is a specific PKC inhibitor (IC50 values: PKCδ 3-6 μM; PKCα, β, γ 30-42 μM; PKCε, η, ζ 80-100 μM). It acts as a direct mitochondrial uncoupler and stimulates autophagy by targeting an upstream mTORC1 signaling cascade. Rottlerin induces apoptosis via caspase 3 activation and inhibits HIV-1 integration and Rabies virus (RABV) infection.

Product Details

Synonyms	Mallotoxin; NSC 56346; NSC 94525
Purity	98.45%
Formula	C30H28O8
Molecular Weight	516.54
SMILES	O=C(C1=C2C(C=CC(C)(C)O2)=C(O)C(CC3=C(O)C(C)=C(O)C(C(C)=O)=C3O)=C1O)/C=C/C4=CC=CC=C4
Appearance	Solid
Color	Brown to reddish brown
Biological Target	PKC; Autophagy; Apoptosis; HIV; RABV
Initial Source	Plants; Euphorbiaceae; Mallotus philippensis
Solubility	DMSO: 12.5 mg/mL (24.20 mM, ultrasonic and warming and heat to 60°C)
Shipping Conditions	Room Temperature
Storage Information	Powder: -80°C, 2 years; -20°C, 1 years. In solvent: -80°C, 6 months; -20°C, 1 month