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Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate convert to saccharopine via lysine-ketoglutarate reductase. Saccharopine then oxidizes to α-aminoapidate semialdehyde and glutamate by saccharopine dehydrogenase. It impairs development by disrupting mitochondrial homeostasis.
| Synonyms | L-Saccharopine |
|---|---|
| Purity | 97.51% |
| Formula | C11H20N2O6 |
| Molecular Weight | 276.29 |
| SMILES | OC([C@@H](NCCCC[C@H](N)C(O)=O)CCC(O)=O)=O |
| Appearance | Solid |
| Color | White to off-white |
| Biological Target | Endogenous Metabolite |
| Target | Human Endogenous Metabolite |
| Initial Source | Endogenous metabolite; Human Gut Microbiota Metabolites |
| Solubility | DMSO: 8.3 mg/mL (30.04 mM, need ultrasonic and warming) |
| Shipping Conditions | Room Temperature |
| Storage Information | -20°C, sealed storage, away from moisture |