SR3335 is a selective RORα partial inverse agonist (IC50 = 480 nM). It inhibits mouse and human TH17 cell development in vitro and in vivo while sparing thymic T cells.
| Formal Name | N-[4-(1, 1, 1, 3, 3, 3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]thiophene-2-sulfonamide |
|---|---|
| Synonyms | ML176 |
| Purity | >98% |
| CAS Number | 293753-05-6 |
| Formula | C13H9F6NO3S2 |
| Molecular Weight | 405.3 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to at least 50 mg/mL) |
| Stability | ≥ 2 years |
| Application Procedures | First, dissolve in DMSO (up to at least 50 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 3 months. |
| Storage Information | -20°C |
RORα partial inverse agonist
Datasheet