SRT1720 is a Sirtuin1 (SIRT1) activator that reduces glucose levels and hyperinsulinemia in obesity models. It inhibits vascular inflammation from angiotensin II-induced atherosclerosis, and reverses abnormal mitochondrial function in neurons exposed to 20-HETE.
| Formal Name | N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2, 1-b][1, 3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide, hydrochloride |
|---|---|
| Synonyms | SIRT 1933 |
| Purity | >98% |
| CAS Number | 1001645-58-4 |
| Formula | C25H23N7OS·HCl |
| Molecular Weight | 506 |
| Appearance | Powder |
| Solubility | Dissolves in DMSO (up to at least 25 mg/mL) |
| Stability | ≥ 1 year |
| Application Procedures | First, dissolve in DMSO (up to at least 25 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 3 months. |
| Storage Information | -20°C |
SIRT1 activator
Datasheet