SU-9516

Cat. No. BIAAA-2505-CXX-23

Package 5 mg/25 mg

Description

This cyclin-dependent kinase inhibitor (IC50s: cdk2 = 0.02–0.03 µM, cdk1 = 0.04–0.2 µM, cdk4 = 0.2–1.7 µM, cdk9 = 0.9 µM) inhibits phosphorylation of retinoblastoma protein (pRb). It down-regulates anti-apoptotic protein Mcl-1, leading to mitochondrial injury and cell death.

Product Details

Formal Name	(Z)-1, 3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one
Purity	>98%
CAS Number	377090-84-1
Formula	C13H11N3O2
Molecular Weight	241.3
Appearance	Powder
Solubility	Dissolves in DMSO (25 mg/mL)
Stability	≥ 2 years
Application Procedures	First, dissolve in DMSO (25 mg/mL), and then dilute it into an aqueous buffer. Solutions in DMSO can be stored at -20°C for up to 2 months.
Storage Information	-20°C

Application

CDK inhibitor (pan-specific)